Chronic Lymphocytic Leukemia

Individualized Lenalidomide Plus Chlorambucil and Rituximab May Be Feasible in Advanced CLL

By James Nam, PharmD September 04, 2018

The feasibility of lenalidomide in combination therapy for chronic lymphocytic leukemia is in question.

Lung Cancer

Capmatinib Plus Gefitinib May Be Effective in Some Forms of Resistant Non-Small Cell Lung Cancer

By James Nam, PharmD September 04, 2018

Capmatinib has demonstrated preclinical activity in EGFR-mutant and MET-activated non-small cell lung cancer when administered with concurrent EGFR-TKIs.

Multiple Myeloma

Cancer-Related Fatigue May Predict Reduced Survival in Newly Diagnosed Multiple Myeloma

By James Nam, PharmD August 31, 2018

Researchers investigated cancer-related fatigue in 16 patients with multiple myeloma who were treated with bortezomib, lenalidomide, or thalidomide.

Skin Cancer

Exploring the Role of Immunotherapy in Melanoma Brain Metastases

By Leah Lawrence August 30, 2018

Although checkpoint inhibitors are active against melanoma-linked brain metastases, researchers are interested in exploring combination approaches.

Multiple Myeloma

Measurement of Excess Abdominal Fat, Not BMI, May Be a More Accurate Risk Factor for Blood Cancers

By Randi Hernandez August 30, 2018

Abdominal adiposity was determined to be a better predictor of risk for hematological malignancies compared with BMI.

Chronic Lymphocytic Leukemia

Ibrutinib May Be Effective in Patients With Chronic Lymphocytic Leukemia Who Were Excluded from Clinical Trials

By James Nam, PharmD August 30, 2018

The RESONATE-2 trial excluded certain patients with chronic lymphocytic leukemia, leaving the efficacy and tolerability of ibrutinib in this population unknown.

Breast Cancer

Breast Cancer Subtype May Be Predictive of Ipsilateral Breast Tumor Recurrence

By James Nam, PharmD August 30, 2018

Radiotherapy after surgery may modify ipsilateral breast tumor recurrence risk among different subtypes of breast cancer.

Practice Management

Medical School Student Loans: Were They Worth It?

By Tom Greenhalgh August 29, 2018

The average indebted medical student owes nearly $190,000 upon graduating. This begs the question: were the loans worth it?

Multiple Myeloma

Evaluation of Available Frontline Induction Therapies for Multiple Myeloma

By James Nam, PharmD August 29, 2018

There is paucity of comparative and efficacy information on novel agents used as frontline induction therapies in multiple myeloma.

Male Reproductive Cancers

Could a Blood Test Help Clinicians Diagnose Multiple Myeloma Earlier?

By Randi Hernandez August 29, 2018

Levels of hemoglobin, combined with ESR, PV, and calcium values, were determined to be the blood parameters with the most diagnostic value in multiple myeloma.

Lung Cancer

S-1 Monotherapy May Be as Effective as Platinum-Based Regimens in Non-Small Cell Lung Cancer

By James Nam, PharmD August 28, 2018

Evidence suggests that S-1 monotherapy may be safe and effective in non-small cell lung cancer.

Hematologic Cancers

Ibrutinib Plus Rituximab Granted FDA Approval for Waldenström Macroglobulinemia

By James Nam, PharmD August 28, 2018

Rituximab plus ibrutinib is the first nonchemotherapy combination regimen approved in Waldenström macroglobulinemia.

Breast Cancer

Radiofrequency Ablation Plus Surgery May Improve Tumor Control in Early-Stage Breast Cancer

By James Nam, PharmD August 27, 2018

Whether radiofrequency ablation is a superior treatment option to lumpectomy requires further investigation.

Hematologic Cancers

Half-Dose R-CHOP May Be Effective, Reduce Toxicity, in Waldenström Macroglobulinemia

By James Nam, PharmD August 27, 2018

Due to its rarity, there is neither robust evidence nor many completed studies supporting specific treatment regimens in Waldenström macroglobulinemia.

Hematologic Cancers

Soluble PD-1 Ligands May Contribute to the Pathogenesis of Waldenström Macroglobulinemia

By Randi Hernandez August 27, 2018

New evidence appears to support the potential utility of checkpoint inhibitors in Waldenström macroglobulinemia.

General Oncology

Care Coordination Recognized as Biggest Safety Concern in Oncology: Study

By Randi Hernandez August 24, 2018

In a recent analysis of VA hospital records, more than half of all oncologic errors and adverse events were attributed to uncoordinated cancer care.

Prostate Cancer

Heavy Alcohol Intake in Early Life May Significantly Increase Odds of High-Grade Prostate Cancer

By James Nam, PharmD August 24, 2018

Recent analyses suggest that lifetime intake and early-life alcohol use may significantly contribute to the development of high-grade prostate cancer.

Fact Sheets

Genetic Testing and Cancer

By Andrea S. Blevins Primeau, PhD, MBA August 24, 2018

Traditional genetic testing historically included the sequential analysis of single and generally well-described genes involved in heritable cancers.

Lung Cancer

Apatinib May Be an Effective Second- or Third-Line Option in Non-Small Cell Lung Cancer

By James Nam, PharmD August 23, 2018

Apatinib has demonstrated efficacy in the second-line setting for gastrointestinal cancers and may also be effective in non-small cell lung cancer.

Skin Cancer

Predictors of Response to Checkpoint Inhibitors in Melanoma Revealed

By Randi Hernandez August 23, 2018

A computational tool appears to accurately tease out the portion of patients who might respond to checkpoint inhibitors from those who are likely to be resistant.

Skin Cancer

Limited Local Lymph Node Excision Plus Radiotherapy May Be Effective in Melanoma

By James Nam, PharmD August 23, 2018

Previous studies have evaluated the effects of limited local node excision plus radiotherapy among patients with melanoma in this subgroup, but had conflicting results.

Practice Management

3 Strategies to Manage Your Student Loan Debt After Medical School

By Tom Greenhalgh August 22, 2018

Most medical school graduates leave school carrying debt. Here's what you can do to better manage your student loan debt.

Lung Cancer

Pembrolizumab Combination for Metastatic NSCLC Upgraded to Full FDA Approval

By James Nam, PharmD August 22, 2018

FDA upgraded the approval of pembrolizumab in combination with pemetrexed and platinum chemotherapy as a first-line treatment for patients with metastatic, nonsquamous NSCLC with no EGFR or ALK genomic tumor aberrations from accelerated to regular approval.

Skin Cancer

Adjuvant Bevacizumab May Not Improve Overall Survival in Resected Melanoma

By James Nam, PharmD August 22, 2018

Previous studies have demonstrated that the vascular endothelial growth factor inhibitor bevacizumab is active in melanoma, and may be effective in the maintenance setting.

Gynecologic Cancer

USPSTF Updates Its Recommendations for Cervical Cancer Screening

By James Nam, PharmD August 21, 2018

The US Preventive Services Task Force conducted a review of trials and cohort studies to support an update of its cervical cancer screening recommendations for women ages 21 to 65 and older.

Chronic Lymphocytic Leukemia

Ibrutinib in Chronic Lymphocytic Leukemia Deemed Not Cost-Effective by ICER Standards

By James Nam, PharmD August 21, 2018

No direct comparison between ibrutinib and chemoimmunotherapy as a first-line treatment exists.

Chronic Lymphocytic Leukemia

Albumin-to-Fibrinogen Ratio May Predict Poor Outcomes in Chronic Lymphocytic Leukemia

By James Nam, PharmD August 21, 2018

Albumin-to-fibrinogen ratio may predict poor outcomes in patients with previously untreated chronic lymphocytic leukemia.

Chronic Lymphocytic Leukemia

In Search of the Right Sequence for Venetoclax in CLL

By Randi Hernandez August 21, 2018

Researchers reveal the results of the phase 2 CLL2-BAG trial, which evaluated sequential bendamustine followed by obinutuzumab and venetoclax in patients with CLL.

General Oncology

Depression as a Side Effect: Exploring a Link Between Certain Cancer Treatments and Mental Health

By Carlos Harrison August 20, 2018

Researchers are promoting physician and patient awareness about the potential tie between depression and certain therapies.

Skin Cancer

Tapping Social Media for Skin Cancer Prevention: What You Can Do

By Tori Rodriguez August 20, 2018

Any images and personal stories that remind people about skin cancer, what to look for, even scars after surgery, really help save lives.

Lung Cancer

FDA Grants Accelerated Approval to Nivolumab for Small Cell Lung Cancer

By James Nam, PharmD August 17, 2018

The decision was based on the ongoing CheckMate-032 phase 1/2 study, in which researchers are investigating nivolumab in patients with advanced or metastatic tumors.

Lung Cancer

Accelerated Intensity-Modulated Radiotherapy May Improve Outcomes in Localized Lung Cancer

By James Nam, PharmD August 17, 2018

Researchers assessed the outcomes of 73 patients with unresectable advanced non-small-cell lung cancer who were treated with 2 different schedules of IMRT: SMART or H-RT.

Gastrointestinal Cancers

FDA Grants Approval to Lenvatinib as First-Line Therapy for Hepatocellular Carcinoma

By James Nam, PharmD August 17, 2018

The FDA based its approval on data from the REFLECT phase 3 study in which investigators enrolled 954 previously untreated patients with metastatic or unresectable hepatocellular carcinoma.

Lung Cancer

COPD May Not Affect Survival in Patients With Small Cell Lung Cancer

By James Nam, PharmD August 17, 2018

There is a lack of data assessing the impact of chronic obstructive pulmonary disorder on mortality in small cell lung cancer.

Multiple Myeloma

Prescription Drug Coverage in Medicare Part D Is Tied to a Survival Advantage in Myeloma

By Randi Hernandez August 17, 2018

Drug coverage status influenced the treatments that were selected for Medicare beneficiaries with myeloma and, consequently, their overall survival.

Fact Sheets

Psychotherapy and Cancer

By Andrea S. Blevins Primeau, PhD, MBA August 17, 2018

Some data suggest that psychotherapy may benefit patients with cancer, but higher-quality research is needed.

General Oncology

Is Paraneoplastic Granuloma Annulare Linked to Solid Organ Malignancies?

By Sheila Jacobs August 17, 2018

Recurrence of GA following cancer treatment should signal the possibility of cancer recurrence.

Multiple Myeloma

Light Therapy May Prevent Depression During Hospitalization Post-Transplant in Multiple Myeloma

By James Nam, PharmD August 16, 2018

Previous studies have suggested that light therapy may improve depression by synchronizing patients' circadian rhythm.

General Oncology

TNFi Not Linked to Increased Risk for Cancer Recurrence in Rheumatoid Arthritis

By Lauren Grygotis August 16, 2018

TNFi treatment is not associated with increased risk for cancer recurrence in patients with rheumatoid arthritis

Bladder Cancer

Immediate Instillation of Mitomycin C Post-TURBT May Benefit All Patients with Bladder Cancer

By James Nam, PharmD August 15, 2018

A reanalysis suggested that an instillation of chemotherapy immediately after surgery may benefit all patients with non-muscle-invasive bladder cancer.

Multiple Myeloma

Lenalidomide-Based Maintenance Therapy May Be the Most Effective in Myeloma

By James Nam, PharmD August 15, 2018

Evidence supporting the overall superiority of a single regimen in the maintenance setting in newly diagnosed multiple myeloma is lacking.

Bladder Cancer

Approximately Two-Thirds of Patients With Stage IV Bladder Cancer Remain Untreated

By Randi Hernandez August 15, 2018

Patients in the SEER-Medicare database with stage IV bladder cancer were found to be less likely to receive chemotherapy than similar cohorts in earlier studies.

Brain Cancer

Where Have All the T Cells Gone?

By Randi Hernandez August 14, 2018

New research proposes a novel mechanism for how tumors sidestep the immune system in patients with intracranial tumors.

Breast Cancer

Religion, Spirituality, May Influence Physical Health Outcomes in Survivors of Breast Cancer

By James Nam, PharmD August 13, 2018

The role and impact of religiousness/spirituality in determining physical well-being among survivors of breast cancer is not well understood.

General Oncology

Study Reveals Scope of Genomic Variation Within Cancer Cell Lines

By Bryant Furlow August 13, 2018

Tumor cell lines derived from single cells and curated at different reference labs have quietly evolved in vitro, accumulating distinct genomic aberrations.

Gynecologic Cancer

Copy Number Abnormalities May Inform Survival, Drug Resistance

By Randi Hernandez August 13, 2018

For cancers associated with numerous copy number changes, it is difficult to assign disease classifiers and identify useful targets for drug development.

Fact Sheets

Polypharmacy and Cancer

By Andrea S. Blevins Primeau, PhD, MBA August 10, 2018

The effect of polypharmacy and noncancer mortality on patient survival and other outcomes in cancer varies by study.

Prostate Cancer

SBRT Appears Effective for Oligometastatic Prostate Cancer

By Jody A. Charnow August 10, 2018

Stereotactic body radiation therapy achieves good local control of metastases in patients with recurrent prostate cancer following primary treatment.

Hematologic Cancers

Intensive Chemotherapy May Not Be Effective in MDS or AML After MDS

By James Nam, PharmD August 10, 2018

Researchers sought to determine the impact of intensive chemotherapy on achieving complete remission and overall survival among patients with MDS or sAML.

Head and Neck Cancer

Novel Biomarker COX-2 May Have a Prognostic Role in Nasopharyngeal Carcinoma

By Randi Hernandez August 10, 2018

The biomarker may be a predictor of response to treatment and cancer progression in nasopharyngeal carcinoma.

Head and Neck Cancer

Recreational Marijuana May Improve Quality of Life Outcomes in Head and Neck Cancer

By James Nam, PharmD August 09, 2018

Previous studies have demonstrated that patients with head and neck cancer experience high levels of stress, anxiety, and psychosocial distress throughout the course of the disease.

Chronic Myeloid Leukemia

Second-Generation TKIs May Be Effective After First-Line Imatinib Failure in Pediatric CML

By James Nam, PharmD August 09, 2018

There is a paucity of data on the use of second-generation tyrosine kinase inhibitors among pediatric patients with chronic-phase chronic myeloid leukemia.

Chronic Myeloid Leukemia

Time of Response to TKI Therapies May Influence Patient Outcomes in CML

By Randi Hernandez August 09, 2018

Early optimal response to TKIs is associated with reductions in treatment failures, poor outcomes, progression of disease, and death.

Lymphoma

FDA Approves Mogamulizumab-kpkc for Rare Subtypes of Non-Hodgkin Lymphoma

By James Nam, PharmD August 09, 2018

Mogamulizumab-kpkc (Poteligeo), a humanized monoclonal antibody that targets CCR4, provides a new treatment option for patients with MF and is the first FDA-approved therapy for SS.

Pancreatic Cancer

Hepatitis B Infection May Increase the Risk for Pancreatic Cancer

By Virginia Schad, PharmD August 09, 2018

Investigators assessed the association of hepatitis B infection and pancreatic cancer, along with predictors of pancreatic cancer and mortality.

Skin Cancer

Frequency of Tanning, Risk for Melanoma Higher in Gym Tanners

By James Nam, PharmD August 08, 2018

The use of tanning beds and/or booths and their availability in gyms may increase the frequency of indoor tanning for physically active adults, a combination that further exacerbates their risk for melanoma.

Sarcoma

Adoptive Cell Therapy in Solid Tumors Demonstrates Robust Antitumor Effects

By Randi Hernandez August 07, 2018

Autologous T cells engineered to recognize a dominant immunogenic antigen in incurable metastatic synovial sarcoma produced lasting antitumor responses.

Gastrointestinal Cancers

Breakthrough Therapy Designation for Encorafenib, Binimetinib, Cetuximab in BRAFV600E-Mutant CRC

By James Nam, PharmD August 07, 2018

Results from a safety lead-in phase conducted prior to a phase 3 trial examining the safety and tolerability of encorafenib, binimetinib, and cetuximab in combination led the FDA to assign the regimen a breakthrough therapy designation.

Practice Management

5 Essential Meditation Apps to Help Unwind In and Out of Your Practice

By Tom Greenhalgh August 07, 2018

Feeling physically and emotionally exhausted? You're not alone. Pull out your smartphone and download these 5 essential meditation apps.

Breast Cancer

High-Risk Breast Cancer Patients May Not Be Adherent to Heart Failure Monitoring

By James Nam, PharmD August 07, 2018

There is a paucity of data regarding the cardiotoxicity and the monitoring adherence habits of patients undergoing treatment with trastuzumab or anthracyclines, commonly used therapies among patients with HER2-positive breast cancer.

Lung Cancer

Heterogeneity of Drug Resistance in EGFR-Mutant Non-Small Cell Lung Cancer

By Randi Hernandez August 07, 2018

The heterogeneity of resistance may make it difficult for drug developers to create combination therapies that prevent eventual resistance to osimertinib.

Multiple Myeloma

The Multiple Myeloma Pipeline: Therapies to Watch

By Randi Hernandez August 06, 2018

New approaches in multiple myeloma have the potential to transform the disease into a chronic condition that can be more easily managed.

Sarcoma

Limb-Sparing Surgery Plus Radiotherapy May Improve Survival Outcomes in Soft-Tissue Sarcoma

By James Nam, PharmD August 06, 2018

Limb-sparing surgery plus radiotherapy, now considered the standard of care to treat patients with extremity soft-tissue sarcoma, leads to improved outcomes, confirmed a recent trial.

Lung Cancer

Lurbinectedin Receives FDA Orphan Drug Status for Recurrent Small-Cell Lung Cancer

By James Nam, PharmD August 06, 2018

Small cell lung cancer, a highly aggressive disease, is diagnosed in 34,000 patients and accounts for nearly 18% of all lung cancer cases in the United States every year.

General Oncology

Pancreatic Cancer and New-Onset Diabetes

By C. Andrew Kistler, MD, PharmD August 03, 2018

New-onset adult diabetes mellitus appears to be both a risk factor for and a sequelae of pancreatic cancer.

Multiple Myeloma

Real-World Data Support Bortezomib Efficacy in Relapsed/Refractory Multiple Myeloma

By James Nam, PharmD August 03, 2018

Although the effectiveness and safety of bortezomib-based therapy for patients with R/R MM has been demonstrated in phase 2 and phase 3 clinical trials, data collected from real-world settings appear to confirm prior study results.

Renal Cell Carcinoma

Biomarkers May Predict Patient Response to Tyrosine Kinase Inhibitors in Metastatic Renal Cell Carcinoma

By Randi Hernandez August 03, 2018

Circulating blood biomarkers related to angiogenesis may help clinicians predict who will have a robust response to sunitinib.

Fact Sheets

Financial Toxicity and Cancer

By Andrea S. Blevins Primeau, PhD, MBA August 02, 2018

Though it is clear that cancer is associated with an extreme financial burden, the extent of the burden varies widely.

Lung Cancer

Osimertinib May Be Effective for CNS Metastases in Non-Small Cell Lung Cancer

By James Nam, PharmD August 02, 2018

Previous studies have demonstrated that osimertinib may have the potential to improve outcomes among patients with central nervous system metastases.

Hematologic Cancers

FDA Assigns a Breakthrough Therapy Designation to Quizartinib for Relapsed/Refractory FLT3-ITD AML

By James Nam, PharmD August 02, 2018

Quizartinib — an investigational FLT3 inhibitor — is the first agent in its class to demonstrate improved overall survival.

Renal Cell Carcinoma

A High Level of Circulating Vitamin D Protein Is Associated With a Decreased Risk of Kidney Cancer

By Randi Hernandez August 02, 2018

Research focused on renal cell carcinoma appears to confirm the potential etiologic role of vitamin D binding protein in cancer.

Bladder Cancer

Robot-Assisted Cystectomy May Lead to Good Surgical, Oncologic Outcomes in Bladder Cancer

By James Nam, PharmD August 01, 2018

With the advent of minimally invasive surgery programs, robotic-assisted radical cystectomy is becoming a point of interest for bladder cancer.

Lung Cancer

Routine, Targeted Next-Generation Sequencing Is Feasible for Patients with Non-Small Cell Lung Cancer

By Randi Hernandez August 01, 2018

Researchers retrospectively examined 2448 cases of NSCLC submitted to a single diagnostics lab over 3 years.

Renal Cell Carcinoma

Lower Costs of Pazopanib for Advanced RCC May Influence Drug Choice

By Leah Lawrence July 31, 2018

Any new study of pazopanib or sunitinib must be placed in perspective of the changing treatment landscape and the market entrance of new immunotherapies.

Bladder Cancer

Factors Associated With Locoregional Recurrence in Muscle-Invasive Bladder Cancer

By James Nam, PharmD July 31, 2018

A better understanding of the factors associated with locoregional recurrence and focused adjuvant therapeutic strategies may lead to enhanced oncologic outcomes.

Prostate Cancer

Active Surveillance May Be a Good Option for Younger Men with Prostate Cancer

By James Nam, PharmD July 31, 2018

The effect of age on outcomes in active surveillance is not well reported and requires further study.

Prostate Cancer

First-Line Enzalutamide May Confer a Survival Benefit for Metastatic Castration-Resistant Prostate Cancer

By Randi Hernandez July 31, 2018

Patients may benefit from earlier lines of enzalutamide for the treatment of metastatic castration-resistant prostate cancer.

Endocrine Cancer

Iobenguane I 131 First FDA-Approved Drug For Pheochromocytoma or Paraganglioma

By James Nam, PharmD July 31, 2018

The FDA based its approval on findings from a single-arm phase 2 study, in which researchers treated 68 patients with iobenguane I 131 intravenous injection.

Hematologic Cancers

Using Autologous Tumor-Infiltrating Lymphocytes to Mediate Tumor Regression: Promising Outcomes in Experimental Research

By Carlos Harrison July 30, 2018

Experimental research may provide a blue print for the treatment of many types of cancer.

Skin Cancer

Do Sunless Tanners Have Fewer Skin Cancer Risk Behaviors?

By James Nam, PharmD July 30, 2018

People who elect to undergo sunless tanning tend to continue behaviors that could increase their risk of skin cancer.

Skin Cancer

Skin Cancer Education May Improve Sun Protection Practices Among Organ Transplant Recipients

By Sheila Jacobs July 30, 2018

The use of multiple sun protection measures was defined as the use of 2 or more of these measures more than 50% of the time when the individual was outdoors.

Bladder Cancer

Bladder Cancer Survival Better Among Married Patients

By Jody A. Charnow July 30, 2018

Widowed patients with bladder urothelial carcinoma have the worst 5-year cancer-specific survival rates among unmarried patients.

Renal Cell Carcinoma

Certain Renal Cancer Subtypes Linked to Obesity

By Jody A. Charnow July 30, 2018

Obesity is associated with an increased likelihood of clear cell and possibly chromophobe renal cell carcinoma.

Hematologic Cancers

Predictors of CAR-T-Associated Neurotoxicity in B-Cell Acute Lymphoblastic Leukemia

By Randi Hernandez July 27, 2018

High levels of CAR-T cell expansion in vivo and high pretreatment disease burden appeared to increase the likelihood that a neurotoxic event may occur following CAR-T administration.

Prostate Cancer

Beverages Sweetened With Added Sugars May Increase the Risk of Prostate Cancer

By James Nam, PharmD July 27, 2018

Some prior evidence has linked increased sugar consumption to cancer development, but its impact on prostate cancer is unknown.

Fact Sheets

Dietary Nitrates/Nitrites and Cancer

By Andrea S. Blevins Primeau, PhD, MBA July 27, 2018

There is concern that added nitrates and nitrites are associated with an increased risk of cancer, but epidemiologic data have been inconclusive thus far.

General Oncology

Do Men Benefit More From Immune Checkpoint Inhibition?

By Bryant Furlow July 26, 2018

A meta-analysis of 20 randomized clinical trials found that men may infer a greater benefit from immune checkpoint inhibition.

General Oncology

Persistent Cancer Screening Gaps Revealed in New CDC Report

By Randi Hernandez July 26, 2018

From 2000 to 2015 screening for breast, cervical, and prostate cancers decreased significantly, whereas screening for colorectal cancer increased significantly.

General Oncology

Population-Level Reductions in Alcohol, Tobacco Use May Reduce Overall Cancer Mortality

By James Nam, PharmD July 26, 2018

There has been little historical evidence to show whether modifying per capita use of alcohol and/or tobacco could affect the cancer mortality rate.

Hematologic Cancers

Ibrutinib Monotherapy Effective in CXCR4- and MYD88-Mutated Waldenström Macroglobulinemia

By James Nam, PharmD July 26, 2018

The effect of MYD88 and CXCR4 mutations on therapy response among patients with treatment-naïve Waldenström macroglobulinemia requires further investigation.

Hematologic Cancers

Waldenström Macroglobulinemia in Europe: Current Practices and Outcomes

By James Nam, PharmD July 25, 2018

A better understanding of current practices may lead to improved, standardized care, as well as better use of health care resources in Waldenström macroglobulinemia.

Prostate Cancer

Gene Variant May Affect Response to Abiraterone in Certain Men with Prostate Cancer

By Leah Lawrence July 25, 2018

The breakdown of the medication abiraterone, which can be accelerated by the presence of a specific gene variant, produces drug metabolites that are suspected to play a role in the progression of prostate cancer to castration-resistant forms of disease.

Hematologic Cancers

Janus Kinase Inhibitors for the Treatment of Myelofibrosis

By Alexander M. Castellino, PhD July 24, 2018

The identification of driver mutations in myelofibrosis has helped cement understanding of the pathophysiology of the disease and has kick-started the development of targeted therapies.

General Oncology

Cancer Mortality Rates Differ Across Racial and Ethnic Subgroups

By Randi Hernandez July 24, 2018

The subtle differences within subsets of populations could tell researchers more about how some cancers affect distinct racial or ethnic populations across a heterogeneous group of minorities.

Lymphoma

Preliminary Topline Results for Tislelizumab in Classical Hodgkin Lymphoma

By Randi Hernandez July 23, 2018

A pivotal phase 2 trial indicates promise for another checkpoint drug, this time for patients with classical Hodgkin lymphoma.

Lung Cancer

The International Association for the Study of Lung Cancer Publishes Liquid Biopsy Recommendations

By Bryant Furlow July 23, 2018

The IASLC released guidance on the use of biopsies for the detection of EGFR and other tumor mutations in patients with NSCLC.

Lung Cancer

Stereotactic Body Radiation Therapy May Improve Overall Survival in Early-Stage Lung Cancer

By James Nam, PharmD July 23, 2018

Though phase 3 studies are ongoing, there is a dearth of evidence that definitively supports the superiority of stereotactic body radiation therapy compared with conventionally fractionated radiation therapy.

Hematologic Cancers

FDA Approves Ivosidenib for IDH1-Mutated Relapsed/Refractory Acute Myeloid Leukemia

By James Nam, PharmD July 20, 2018

Ivosidenib is the first-in-class FDA approval for IDH1 mutation-harboring acute myeloid leukemia.

Chronic Lymphocytic Leukemia

Clinical Stage at First Response May Predict Outcomes in Chronic Lymphocytic Leukemia

By James Nam, PharmD July 20, 2018

Clinical stage determined by the Binet staging system could be an accurate response surrogate among patients with chronic lymphocytic leukemia.

Fact Sheets

Exercise and Cancer

By Andrea S. Blevins Primeau, PhD, MBA July 20, 2018

The mechanisms that drive this benefit are not well-understood, and it is believed that the benefit is not just a result of reducing risk factors such as body weight.

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